Prescription opioid overdose, misuse, and dependence cost the U.S over $78 billion a year in health care, criminal justice, and lost productivity costs. -Source: Curtis S. Florence et al."The Economic Burden of Prescription Opioid Overdose, Abuse, and Dependence in the United States, 2013" -Medical Care 54m, no. 10 (2016): 901-6